ReviewBiochemistry

Extracellular Phosphorylation and Phosphorylated Proteins: Not Just Curiosities But Physiologically Important

Science Signaling  18 Dec 2012:
Vol. 5, Issue 255, pp. re7
DOI: 10.1126/scisignal.2003273

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Gloss

With 3 figures, 1 table, and 221 references plus 2 supplementary figures and 1 supplementary table, this Review describes the evidence supporting physiological and pathological functions of phosphorylated extracellular proteins. In addition, evidence for extracellular phosphorylation in various contexts and tissues is also presented. To facilitate the study of the extracellular phosphoproteome, annotation of the phosphorylated proteins found in proteomic databases is supplied.