Science Signaling Podcast: 15 January 2013

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Sci. Signal.  15 Jan 2013:
Vol. 6, Issue 258, pp. pc2
DOI: 10.1126/scisignal.2003894

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This Podcast features an interview with Gabriel Núñez, senior author of a Research Resource published in the 15 January 2013 issue of Science Signaling. A group led by Núñez has performed a screen to identify regulators of the NOD2 and NF-κB signaling pathways. Signaling through NOD2 and NF-κB induces normal inflammatory responses, but mutations that alter the activity of NOD2 have been associated with inflammatory disorders such as Blau syndrome and Crohn's disease. The results of this screen help shed light on the genetic basis of inflammatory disease and offer potential targets for understanding and treating such disorders.

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