PerspectiveCOMPUTATIONAL BIOLOGY

Therapeutic Hints from Analyzing the Attractor Landscape of the p53 Regulatory Circuit

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Sci. Signal.  05 Feb 2013:
Vol. 6, Issue 261, pp. pe5
DOI: 10.1126/scisignal.2003820

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Abstract

Genes are interconnected in the cell to form a genetic network that regulates cell fate. Targeting multiple genes is expected to be more effective in developing therapeutics than targeting single genes. A recent study demonstrated the possibility of systematically searching for such combinatorial treatments by characterizing the attractor landscape of the p53 regulatory circuit.

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