12 February 2013
Vol 6, Issue 262

About The Cover

Cover image expansion

Online Cover This week features a Research Article (also listen to the accompanying Podcast) describing how HIF-1α inhibits a helicase complex that unwinds DNA in preparation for replication through a nontranscriptional mechanism, thereby inducing cell cycle arrest during hypoxia. The image is an artist's depiction of replicating DNA. [Image: Yana Hammond/Science Signaling]