PodcastCell Biology

Science Signaling Podcast: 12 February 2013

Sci. Signal.  12 Feb 2013:
Vol. 6, Issue 262, pp. pc5
DOI: 10.1126/scisignal.2004007

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Abstract

This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

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