Editors' ChoiceCancer

Genetic Clues to Meningioma

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Sci. Signal.  05 Mar 2013:
Vol. 6, Issue 265, pp. ec60
DOI: 10.1126/scisignal.2004116

Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neurofibromin 2 gene (NF2). To identify other genes that contribute to meningioma pathogenesis, Clark et al. performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base—which tend to harbor mutations in the TRAF7, KLF4, AKT1, and SMO genes—and higher-grade tumors located in the cerebral and cerebellar hemispheres that harbor mutations in NF2.

V. E. Clark, E. Z. Erson-Omay, A. Serin, J. Yin, J. Cotney, K. Özduman, T. Avşar, J. Li, P. B. Murray, O. Henegariu, S. Yilmaz, J. M. Günel, G. Carrión-Grant, B. Yılmaz, C. Grady, B. Tanrıkulu, M. Bakırcıoğlu, H. Kaymakçalan, A. O. Caglayan, L. Sencar, E. Ceyhun, A. F. Atik, Y. Bayri, H. Bai, L. E. Kolb, R. M. Hebert, S. B. Omay, K. Mishra-Gorur, M. Choi, J. D. Overton, E. C. Holland, S. Mane, M. W. State, K. Bilgüvar, J. M. Baehring, P. H. Gutin, J. M. Piepmeier, A. Vortmeyer, C. W. Brennan, M. N. Pamir, T. Kılıç, R. P. Lifton, J. P. Noonan, K. Yasuno, M. Günel, Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339, 1077–1080 (2013). [Abstract] [Full Text]