Science Signaling Podcast: 19 March 2013

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Sci. Signal.  19 Mar 2013:
Vol. 6, Issue 267, pp. pc8
DOI: 10.1126/scisignal.2004109

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This Podcast features an interview with Ching-Shih Chen, senior author of a Research Article that appears in the 19 March 2013 issue of Science Signaling. Huang et al. report that the α and γ forms of tocopherol, which is a lipophilic molecule and dietary form of vitamin E, promoted dephosphorylation of the growth-promoting kinase Akt. Tocopherols bound to both Akt and the phosphatase PHLPP1 and recruited them to the plasma membrane, where PHLPP1 dephosphorylated Akt on Ser473, thus inactivating Akt. This reduced the proliferation of cultured prostate cancer cells and reduced the growth of prostate tumors xenografted into mice. The authors developed a synthetic derivative of γ-tocopherol that exhibited greater potency than natural tocopherols in this context, suggesting that the development of drugs structurally related to tocopherols might benefit the treatment of prostate and other cancers that are driven by Akt activity.

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