Editorial GuideCancer

Focus Issue: From Genomic Mutations to Oncogenic Pathways

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Sci. Signal.  26 Mar 2013:
Vol. 6, Issue 268, pp. eg3
DOI: 10.1126/scisignal.2004149

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This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.

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