Science Signaling Podcast: 2 April 2013

Science Signaling  02 Apr 2013:
Vol. 6, Issue 269, pp. pc9
DOI: 10.1126/scisignal.2004156

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This Podcast features an interview with Risheng Xu, first author of a Research Article that appears in the 2 April 2013 issue of Science Signaling. The transcription factor p53 is tumor suppressor that is activated by various cell stresses, and it promotes the transcription of genes that participate in DNA damage repair, cell cycle arrest, and apoptosis. At target gene promoters, p53 cooperates with the acetyltransferase p300 to stimulate the expression of genes required for these stress responses. In a new study published this week in Science Signaling, Risheng Xu and colleagues report that the multifunctional protein IPMK (inositol polyphosphate multikinase) stimulates p53 activity at target gene promoters by recruiting p300 into this transcriptional complex.

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