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Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death

Science Signaling  02 Apr 2013:
Vol. 6, Issue 269, pp. ra22
DOI: 10.1126/scisignal.2003405

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Activating p53 with IMPK

The transcription factor p53 mediates cell death in response to cellular stress. Xu et al. found that the transcriptional activity of p53 was enhanced by inositol polyphosphate multikinase (IPMK). IPMK bound to p53 directly and stimulated its acetylation by the acetyltransferase p300. Loss of IPMK or disruption of the IPMK-p53 interaction decreased acetylation of both p53 and the promoters of its target genes, reduced the transcription of p53 target genes, and decreased p53-mediated apoptosis. Thus, IPMK functions as a transcriptional coactivator of p53.