Research ResourceSystems Biology

The switches.ELM Resource: A Compendium of Conditional Regulatory Interaction Interfaces

Sci. Signal.  02 Apr 2013:
Vol. 6, Issue 269, pp. rs7
DOI: 10.1126/scisignal.2003345

You are currently viewing the editor's summary.

View Full Text

Investigating Biological Switches

Pre- and posttranslational mechanisms change the activity of proteins and can alter the functional interaction between them, thereby altering the physiological outcome of cellular signals. Van Roey et al. developed an online database and tool, “switches.ELM,” that contains a repository of experimentally validated mechanisms that dynamically regulate the functional states of short linear motifs (SLiMs), sites of protein-ligand binding, and rules for how these motifs function as cellular switches. Thus, the switches.ELM resource enables analysis of how protein interactions function in cellular decision-making.