PerspectiveDevelopmental Biology

Turing and Wolpert Work Together During Limb Development

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Sci. Signal.  09 Apr 2013:
Vol. 6, Issue 270, pp. pe14
DOI: 10.1126/scisignal.2004038

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Limb development has been widely studied in developmental biology. Two types of theories, one based on positional information and another based on spontaneous pattern formation, are utilized to understand this process. However, for historical reasons, these two concepts are regarded as mutually exclusive. By considering the interaction between these two mechanisms with quantitative morphological data, we can experimentally explore how the vertebrate limb skeletal pattern is established from a new direction.

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