PodcastCell Biology

Science Signaling Podcast: 16 April 2013

Science Signaling  16 Apr 2013:
Vol. 6, Issue 271, pp. pc10
DOI: 10.1126/scisignal.2004186

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Abstract

This Podcast features an interview with Guanglei Zhuang and Napoleone Ferrara, authors of a Research Article that appears in the 16 April 2013 issue of Science Signaling. Zhuang and Ferrara discuss results from their analysis of the temporal dynamics of protein phosphorylation events downstream of vascular endothelial growth factor (VEGF) receptor activation. VEGFs are secreted growth factors that promote angiogenesis, and they promote growth of blood vessels during normal development, in wound healing, and into tissues that are deprived of oxygen. VEGF-mediated vascularization of tumors is implicated in cancer growth and progression, and VEGFs play a role in pathologies that are characterized by the abnormal growth of blood vessels, such as diabetic retinopathy and age-related macular degeneration. Drugs that inhibit VEGF or block the activity of signaling proteins downstream of VEGF receptors are used clinically to block VEGF activity in the context of pathologic vascularization. Thus, understanding the intricacies of VEGF signaling is important for devising new ways to treat VEGF-dependent vascular pathologies.

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