Signaling Mechanisms in Mammalian Myoblast Fusion

Sci. Signal., 23 April 2013
Vol. 6, Issue 272, p. re2
DOI: 10.1126/scisignal.2003832

Signaling Mechanisms in Mammalian Myoblast Fusion

  1. Sajedah M. Hindi,
  2. Marjan M. Tajrishi, and
  3. Ashok Kumar*
  1. Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
  1. *Corresponding author. E-mail: ashok.kumar{at}


Skeletal muscles are formed by the fusion of multiple myoblasts during development. Myoblast fusion is also essential for the growth and repair of injured myofibers. Recent investigations have shown that the process of myoblast fusion involves the activation of several cell signaling pathways, including those mediated by nuclear factor κB, mitogen-activated protein kinases, Wnt, calcineurin–nuclear factor of activated T cells c2, transforming growth factor–β–Smad4, and the Rho guanosine triphosphatases. In this Review, which contains 2 figures and 84 references, we summarize the mechanisms by which the activation of these signaling pathways stimulates myoblast fusion.


S. M. Hindi, M. M. Tajrishi, and A. Kumar, Signaling Mechanisms in Mammalian Myoblast Fusion. Sci. Signal. 6, re2 (2013).

Protein O-Fucosyltransferase 1 Expression Impacts Myogenic C2C12 Cell Commitment via the Notch Signaling Pathway
A. Der Vartanian, A. Audfray, B. Al Jaam, M. Janot, S. Legardinier, A. Maftah, and A. Germot
Mol. Cell. Biol. 35, 391-405 (15 January 2015)

Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1
A.-N. Takeda, T. K. Oberoi-Khanuja, G. Glatz, K. Schulenburg, R.-P. Scholz, A. Carpy, B. Macek, A. Remenyi, and K. Rajalingam
EMBO J. 33, 1784-1801 (18 August 2014)

Myomaker is essential for muscle regeneration
D. P. Millay, L. B. Sutherland, R. Bassel-Duby, and E. N. Olson
Genes Dev. 28, 1641-1646 (1 August 2014)

Identification of the crucial molecular events during the large-scale myoblast fusion in sheep
C. Wei, L. Li, H. Su, L. Xu, J. Lu, L. Zhang, W. Liu, H. Ren, and L. Du
Physiol. Genomics 46, 429-440 (1 June 2014)

Efficient Reovirus- and Measles Virus-Mediated Pore Expansion during Syncytium Formation Is Dependent on Annexin A1 and Intracellular Calcium
M. Ciechonska, T. Key, and R. Duncan
J. Virol. 88, 6137-6147 (1 June 2014)

Low-Dose Benzo(a)pyrene and Its Epoxide Metabolite Inhibit Myogenic Differentiation in Human Skeletal Muscle-Derived Progenitor Cells
C.-Y. Chiu, Y.-P. Yen, K.-S. Tsai, R.-S. Yang, and S.-H. Liu
Toxicol Sci 138, 344-353 (1 April 2014)

Activation of alternative NF-{kappa}B signaling during recovery of disuse-induced loss of muscle oxidative phenotype
A. H. V. Remels, N. A. Pansters, H. R. Gosker, A. M. W. J. Schols, and R. C. J. Langen
Am. J. Physiol. Endocrinol. Metab. 306, E615-E626 (15 March 2014)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882