Editors' ChoiceCircadian Biology


Sci. Signal.  21 May 2013:
Vol. 6, Issue 276, pp. ec114
DOI: 10.1126/scisignal.2004333

Although core components of circadian clocks in flies and mammals are transcriptional circuits, recent evidence indicates that posttranscriptional regulation of the clock occurs. Studies from Lim and Allada and Zhang et al. converge to show that the protein ATAXIN-2, associated with neurodegenerative diseases in humans, is a regulator of translation required for normal clock function in pacemaker neurons and for daily rhythms of behavior. ATAXIN is an RNA-binding protein and cooperates in the accumulation of the Per (Period) protein, a core transcriptional regulatory component of the clock.

C. Lim, R. Allada, ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila. Science 340, 875–879 (2013). [Abstract] [Full Text]

Y. Zhang, J. Ling, C. Yuan, R. Dubruille, P. Emery, A role for Drosophila ATX2 in activation of PER translation and circadian behavior. Science 340, 879–882 (2013). [Abstract] [Full Text]