PerspectiveDevelopmental Biology

Understanding the Determinants of Notch Interactions with Its Ligands

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Sci. Signal.  21 May 2013:
Vol. 6, Issue 276, pp. pe19
DOI: 10.1126/scisignal.2004079

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Abstract

The Notch signaling pathway involves ligand-activated cleavage of the receptor Notch and the interaction of the intracellular fragment with the transcriptional regulators CSL and Mastermind. Additional complexity in the system arises through the differential interaction of Notch with its ligands of the Delta and Serrate families. Glycosylation of the extracellular portion of Notch by Fringe proteins contributes to receptor selectivity toward its ligands. Recent research suggests that a glycosylation-independent function of the Notch epidermal growth factor repeats also plays an important role in specifying activation of Notch by Ser.

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