PodcastBiochemistry

Science Signaling Podcast: 28 May 2013

Sci. Signal.  28 May 2013:
Vol. 6, Issue 277, pp. pc14
DOI: 10.1126/scisignal.2004316

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Abstract

This Podcast features an interview with Steven Balk, senior author of a Research Article that appears in the 28 May 2013 issue of Science Signaling. BMX (bone marrow tyrosine kinase gene on chromosome X) is a protein tyrosine kinase that can be activated downstream of phosphatidylinositol 3-kinase and the kinase Src, but not much is known about its substrates. In a study by Chen et al. published this week in Science Signaling, Steven Balk's group reports that BMX preferentially phosphorylates other tyrosine kinases on primed tyrosines, which are unphosphorylated tyrosine residues that are located next to phosphorylated tyrosine residues. The authors demonstrate that BMX promotes maximal signaling by the receptor tyrosine kinase FAK and the insulin receptor. Several other tyrosine kinase receptors contain such primed tyrosine motifs, implying that BMX may regulate signaling through various signaling pathways.

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