Editors' ChoiceHost-Pathogen Interactions

Bacterial Subversion Tactics

Sci. Signal.  06 Aug 2013:
Vol. 6, Issue 287, pp. ec186
DOI: 10.1126/scisignal.2004585

Intracellular bacterial pathogens such as Listeria monocytogenes can change host cell transcription programs to promote infection. Eskandarian et al. found that during infection, the Listeria effector protein InlB promoted the movement of a host protein deacetylase, SIRT2, from its normal location in the cytosol to the nucleus. In the nucleus, SIRT2 helped to repress a number of host cell genes by deacetylating one of their associated histones. In mice, reduced levels of SIRT2 impaired bacterial infection.

H. A. Eskandarian, F. Impens, M.-A. Nahori, G. Soubigou, J.-Y. Coppée, P. Cossart, M. A. Hamon, A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science 341, 1238858 (2013). [Abstract] [Full Text]