Contents

Contents

• Research Articles

  • Computational Modeling of ERBB2-Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors

    By Daniel C. Kirouac, Jin Y. Du, Johanna Lahdenranta, Ryan Overland, Defne Yarar, Violette Paragas, Emily Pace, Charlotte F. McDonagh, Ulrik B. Nielsen, Matthew D. Onsum

    Sci. Signal.13 Aug 2013 : ra68 Full AccessRestricted Access

    Computational modeling of signaling feedback in ErbB2-positive breast cancer predicts improved combination therapies.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • A Computational Model Predicts That Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels

    By Rahul Mahajan, Junghoon Ha, Miao Zhang, Takeharu Kawano, Tohru Kozasa, Diomedes E. Logothetis

    Sci. Signal.13 Aug 2013 : ra69 Full AccessRestricted Access

    Multistage computational docking reveals how a potassium channel is activated by Gβγ.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Resolving Molecular Events in the Regulation of Meiosis in Male and Female Germ Cells

    By Sandeep Kumar, Thomas J. Cunningham, Gregg Duester

    Sci. Signal.13 Aug 2013 : pe25 Full AccessRestricted Access

    Genetic and pharmacological studies produce conflicting results regarding a role for retinoic acid in meiosis of the female germ cells.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 13 August 2013

    By Diomedes E. Logothetis, Rahul Mahajan, Annalisa M. VanHook

    Science Signaling13 Aug 2013 : pc21 Full AccessRestricted Access

    Structural modeling reveals how G proteins activate a potassium channel to slow heart rate.

    • Abstract
    • Full Text

• Editors' Choice

  • Fueling Cancer Growth

    By Wei Wong

    Sci. Signal.13 Aug 2013 : ec188 Full AccessRestricted Access

    Tumors in insulin-resistant tissues may maintain insulin sensitivity through Wnt-mediated activation of the gene encoding the insulin receptor.

    • Abstract

  • Fatty Acids as Environmental Cues?

    By Annalisa M. VanHook

    Science Signaling13 Aug 2013 : ec189 Full AccessRestricted Access

    Long-chain unsaturated free fatty acids inhibit the expression of Salmonella virulence genes through the PhoP/PhoQ system.

    • Abstract

  • Protecting the Endothelium

    By Leslie K. Ferrarelli

    Sci. Signal.13 Aug 2013 : ec190 Full AccessRestricted Access

    Two membrane receptors interact to maintain endothelial monolayer integrity in the vasculature.

    • Abstract

  • T Cells TAMing Dendritic Cells

    By John F. Foley

    Science Signaling13 Aug 2013 : ec191 Full AccessRestricted Access

    Antigen-specific production of Protein S by activated T cells signals through dendritic cell receptors to dampen the immune response.

    • Abstract

• Erratum

  • A Correction to the Research Article Titled: ”β-Arrestin–Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6” by E. M. Borroni, C. Cancellieri, A. Vacchini, Y. Benureau, B. Lagane, F. Bachelerie, F. Arenzana-Seisdedos, K. Mizuno, A. Mantovani, R. Bonecchi, M. Locati

    Science Signaling13 Aug 2013 : er5 Full AccessRestricted Access

    Corrections to Figs. 2, 4, 5, and 6, as well as the legends to Figs. 2 and 4, are made.

    • Full Text
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