Contents
Vol 6, Issue 288
Contents
Research Articles
- Computational Modeling of ERBB2-Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors
Computational modeling of signaling feedback in ErbB2-positive breast cancer predicts improved combination therapies.
- A Computational Model Predicts That Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels
Multistage computational docking reveals how a potassium channel is activated by Gβγ.
Perspective
- Resolving Molecular Events in the Regulation of Meiosis in Male and Female Germ Cells
Genetic and pharmacological studies produce conflicting results regarding a role for retinoic acid in meiosis of the female germ cells.
Podcast
- Science Signaling Podcast: 13 August 2013
Structural modeling reveals how G proteins activate a potassium channel to slow heart rate.
Editors' Choice
- Fueling Cancer Growth
Tumors in insulin-resistant tissues may maintain insulin sensitivity through Wnt-mediated activation of the gene encoding the insulin receptor.
- Fatty Acids as Environmental Cues?
Long-chain unsaturated free fatty acids inhibit the expression of Salmonella virulence genes through the PhoP/PhoQ system.
- Protecting the Endothelium
Two membrane receptors interact to maintain endothelial monolayer integrity in the vasculature.
- T Cells TAMing Dendritic Cells
Antigen-specific production of Protein S by activated T cells signals through dendritic cell receptors to dampen the immune response.
Erratum
- A Correction to the Research Article Titled: ”β-Arrestin–Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6” by E. M. Borroni, C. Cancellieri, A. Vacchini, Y. Benureau, B. Lagane, F. Bachelerie, F. Arenzana-Seisdedos, K. Mizuno, A. Mantovani, R. Bonecchi, M. Locati
Corrections to Figs. 2, 4, 5, and 6, as well as the legends to Figs. 2 and 4, are made.