Editors' ChoiceNoncoding RNAs

A New Linc in Innate Immunity

Sci. Signal.  20 Aug 2013:
Vol. 6, Issue 289, pp. ec197
DOI: 10.1126/scisignal.2004638

Long noncoding RNAs (lncRNAs) have recently emerged as important regulators of gene expression in a wide variety of biological processes, although specific roles for these molecules in the immune system have not been described. Carpenter et al. now define the function of one such lncRNA in the immune system, lincRNA-Cox2. Whole-transcriptome profiling revealed that lincRNA-Cox2 was induced in mouse macrophages in response to activation of Toll-like receptors—molecules that detect microbes and alert the immune system to respond. LincRNA-Cox2 both positively and negatively regulated the expression of distinct groups of inflammatory genes. Negative regulation of gene expression was mediated by lincRNA-Cox interaction with heterogeneous nuclear ribonucleoprotein A/B and A2/B1.

S. Carpenter, D. Aiello, M. K. Atianand, E. P. Ricci, P. Gandhi, L. L. Hall, M. Byron, B. Monks, M. Henry-Bezy, J. B. Lawrence, L. A. J. O’Neill, M. J. Moore, D. R. Caffrey, K. A. Fitzgerald, A long noncoding RNA mediates both activation and repression of immune response genes. Science 341, 789–792 (2013). [Abstract] [Full Text]

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