ReviewNoncoding RNAs

Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis

Sci. Signal.  20 Aug 2013:
Vol. 6, Issue 289, pp. re5
DOI: 10.1126/scisignal.2004099

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Long noncoding RNAs (lncRNAs) are a class of transcripts that do not encode proteins and are greater than 200 nucleotides in length. Accumulating evidence suggests that lncRNAs are involved in normal development and in disease progression, including normal and malignant hematopoiesis. In this Review with 2 figures, 2 tables, and 87 references, we describe the progress in understanding the roles of lncRNAs in hematopoiesis and blood cell signaling. We also discuss the current and potential future application of lncRNAs as diagnostic and prognostic indicators in malignant hematopoiesis, as well as the prospect that lncRNAs may serve as therapeutic targets in leukemia and other blood diseases.