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Science Signaling Podcast: 27 August 2013

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Sci. Signal.  27 Aug 2013:
Vol. 6, Issue 290, pp. pc22
DOI: 10.1126/scisignal.2004626

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Abstract

This Podcast features an interview with Peixin Yang and Albert Reece, authors of a Research Article that appears in the 27 August 2013 issue of Science Signaling. Neural tube defects are among the most common types of birth defects and can be caused by toxins, vitamin deficiencies, or maternal factors such as diabetes. In vertebrate embryos, the neural plate folds over on itself to form the neural tube, a structure that gives rise to the brain and spinal cord. Incomplete closure of the neural tube causes conditions such as spina bifida or anencephaly, depending upon when and where the defect occurs. In humans, maternal hyperglycemia is associated with an increased risk for neural tube defects. In this issue of Science Signaling, Yang et al. report a mechanism by which maternal diabetes can cause neural tube defects in mice.

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