PerspectiveImmunology

Nutrient Regulation of Immunity: O-GlcNAcylation Regulates Stimulus-Specific NF-κB–Dependent Transcription

See allHide authors and affiliations

Sci. Signal.  27 Aug 2013:
Vol. 6, Issue 290, pp. pe26
DOI: 10.1126/scisignal.2004596

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Nutrients regulate gene transcription by the dynamic cycling of O-linked N-acetylglucosamine (O-GlcNAc) on proteins that constitute the transcriptional machinery. A study shows that O-GlcNAcylation of the nuclear factor κB (NF-κB) subunit c-Rel is required for its binding to the promoters of some, but not all, key T cell receptor–dependent genes; however, O-GlcNAcylation is dispensable for the binding of c-Rel to the promoters of tumor necrosis factor–α–dependent genes. This study not only illustrates how specific stimuli that act on the same transcription factor can elicit the expression of particular sets of genes, it also suggests a possible mechanism for autoimmunity in diabetes.

View Full Text