Editors' ChoiceMechanotransduction

Lamins and Tissue Stiffness

Sci. Signal.  03 Sep 2013:
Vol. 6, Issue 291, pp. ec211
DOI: 10.1126/scisignal.2004687

Microenvironment can influence cell fate and behavior; for example, extracellular matrix (ECM) stiffness increases cell proliferation, and ECM rigidity induces disorders in tissue morphogenesis by increasing cell tension. Swift et al. (see the Perspective by Bainer and Weaver) used proteomics to identify molecules that are mechanical sensors for tissue elasticity in the nucleus and discovered that expression of lamin-A levels apparently functions as a “mechanostat.”

J. Swift, I. L. Ivanovska, A. Buxboim, T. Harada, P. C. D. P. Dingal, J. Pinter, J. D. Pajerowski, K. R. Spinler, J.-W. Shin, M. Tewari, F. Rehfeldt, D. W. Speicher, D. E. Discher, Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science 341, 1240104 (2013). [Abstract] [Full Text]

R. Bainer, V. Weaver, Strength under tension. Science 341, 965–966 (2013). [Abstract] [Full Text]