PerspectiveDNA damage

Brd4 Shields Chromatin from ATM Kinase Signaling Storms

See allHide authors and affiliations

Sci. Signal.  17 Sep 2013:
Vol. 6, Issue 293, pp. pe30
DOI: 10.1126/scisignal.2004622

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.

View Full Text