PodcastImmunology

Science Signaling Podcast: 1 October 2013

Science Signaling  01 Oct 2013:
Vol. 6, Issue 295, pp. pc26
DOI: 10.1126/scisignal.2004729

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

This Podcast features an interview with Carlos Gorbea, author of a Research Article that appears in the 1 October 2013 issue of Science Signaling on the role of proteasomes in TLR3 signaling. TLR3 is a member of the Toll-like receptor family, which is a group of related receptors that detect the presence of pathogens and trigger innate immune responses. TLR3 is localized to endosomes and activated by binding to double-stranded RNA, which is the genetic material of some viruses. Gorbea and colleagues found that depletion of Ecm29, which is an adaptor protein associated with a subset of 26S proteasomes, increased TLR3 signaling by inhibiting both the proteasomal degradation of TLR3 effectors and the autophagic degradation of TLR3 and TLR3 effectors.

View Full Text

Related Content