ReviewDevelopmental Biology

Hippo Gains Weight: Added Insights and Complexity to Pathway Control

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Sci. Signal.  08 Oct 2013:
Vol. 6, Issue 296, pp. re7
DOI: 10.1126/scisignal.2004208

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Abstract

The Hippo pathway is a kinase cascade, formed by Hippo, Salvador, Warts, and Mats, that regulates the subcellular distribution and transcriptional activity of Yorkie. Yorkie is a transcriptional coactivator that promotes the expression of genes that inhibit apoptosis and drive cell proliferation. We review recent studies indicating that activity of the Hippo pathway is controlled by cell-cell junctions, cell adhesion molecules, scaffolding proteins, and cytoskeletal proteins, as well as by regulators of apical-basal polarity and extracellular tension.

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