Wiring the Retina

Sci. Signal.  05 Nov 2013:
Vol. 6, Issue 300, pp. ec269
DOI: 10.1126/scisignal.2004874

Starburst amacrine cells in the retina detect motion by responding to light going on or off. Sun et al. analyzed how the cellular circuits develop in the mouse retina to form the basis of motion detection. Expression patterns of semaphorin 6A and its receptor plexin A2 defined the shape and reactivity of the starburst amacrine cells. Semaphorin 6A expression was restricted to particular cells, generating two classes of starburst amacrine cells with distinct morphologies and opposing functions.

L. O. Sun, Z. Jiang, M. Rivlin-Etzion, R. Hand, C. M. Brady, R. L. Matsuoka, K.-W. Yau, M. B. Feller, A. L. Kolodkin, On and off retinal circuit assembly by divergent molecular mechanisms. Science 342, 1241974 (2013). [Abstract] [Full Text]