Editors' ChoicePlant biology

First Defense

Sci. Signal.  05 Nov 2013:
Vol. 6, Issue 300, pp. ec271
DOI: 10.1126/scisignal.2004873

In defense against bacterial infection, plants carry a cell-surface receptor, known as FLS2, that can bind to a fragment of bacterial flagellin and trigger defense responses. Sun et al. investigated the structural details that govern the binding between FLS2, its co-receptor BAK1, and the flagellin fragment flg22. The assembled complex initiates signals to activate the plant’s innate immune response.

Y. Sun, L. Li, A. P. Macho, Z. Han, Z. Hu, C. Zipfel, J.-M. Zhou, J. Chai, Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 342, 624–628 (2013). [Abstract] [Full Text]