Editors' ChoiceHost-Microbe Interactions

Command and Control

Sci. Signal.  10 Dec 2013:
Vol. 6, Issue 305, pp. ec302
DOI: 10.1126/scisignal.2004974

Innate lymphoid cells are vital for the development of gut-associated lymphoid tissues, maintenance of the epithelial barrier, and protection against intestinal microbes; their dysfunction can promote immune pathology. Immunoglobulin A (IgA) production is important for maintenance of the gut epithelial barrier and the composition of the gut microbiota. Through the generation of knockout mouse models, Kruglov et al. were able to distinguish how soluble and membrane-bound lymphotoxins expressed by innate lymphoid cells in the gut specifically regulate IgA production and thereby control gut microbiota composition.

A. A. Kruglov, S. I. Grivennikov, D. V. Kuprash, C. Winsauer, S. Prepens, G. M. Seleznik, G. Eberl, D. R. Littman, M. Heikenwalder, A. V. Tumanov, S. A. Nedospasov, Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science 342, 1243–1246 (2013). [Abstract] [Full Text]