Editors' ChoiceImmunology

Hedgehog View to a Kill

Sci. Signal.  10 Dec 2013:
Vol. 6, Issue 305, pp. ec303
DOI: 10.1126/scisignal.2004971

Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. de la Roche et al. (see the Perspective by Le Borgne and Shaw) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired.

M. de la Roche, A. T. Ritter, K. L. Angus, C. Dinsmore, C. H. Earnshaw, J. F. Reiter, G. M. Griffiths, Hedgehog signaling controls T cell killing at the immunological synapse. Science 342, 1247–1250 (2013). [Abstract] [Full Text]

M. Le Borgne, A. S. Shaw, Do T cells have a cilium? Science 342, 1177–1178 (2013). [Abstract] [Full Text]