Science Signaling Podcast: 10 December 2013

See allHide authors and affiliations

Sci. Signal.  10 Dec 2013:
Vol. 6, Issue 305, pp. pc33
DOI: 10.1126/scisignal.2004950

You are currently viewing the abstract.

View Full Text


This is an interview with Judith Davie, senior author of a Research Article published in the 10 December 2013 issue of Science Signaling, about how an inflammatory cytokine interferes with muscle repair. Inflammatory cytokines are produced at sites of infection and tissue damage, and they promote the inflammatory processes that fight pathogens and initiate tissue repair. When skeletal muscles are damaged, they secrete the inflammatory cytokine interferon-γ (IFN-γ), which helps muscles heal. Although transient production of IFN-γ is required for repairing damaged muscle, too much of it hinders repair. Priya Londhe and Judith Davie report that excess IFN-γ represses the expression of muscle-specific genes that are required for the differentation of new muscle cells.

View Full Text