Editors' ChoiceCell Biology

EMRE Emerges

Sci. Signal.  17 Dec 2013:
Vol. 6, Issue 306, pp. ec310
DOI: 10.1126/scisignal.2005002

Concentrations of calcium within mitochondria are tightly regulated and modulate physiological mitochondrial functions, including control of metabolism and cell death. Sancak et al. complete the molecular characterization of the mitochondrial calcium uniporter (MCU), the multicomponent channel that allows concentration of calcium within the organelle. They identified a small protein termed “essential MCU regulator”—or EMRE—which was required for calcium transport activity of the fully assembled uniporter.

Y. Sancak, A. L. Markhard, T. Kitami, E. Kovács-Bogdán, K. J. Kamer, N. D. Udeshi, S. A. Carr, D. Chaudhuri, D. E. Clapham, A. A. Li, S. E. Calvo, O. Goldberger, V. K. Mootha, EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342, 1379–1382 (2013). [Abstract] [Full Text]