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This Podcast features an interview with Eric Klann and Moses Chao, authors of a Research Article that appears in the 14 January 2014 issue of Science Signaling, about a signaling pathway that plays a role in mediating some of the effects of the antipsychotic drug haloperidol. First-generation antipsychotic drugs such as haloperidol block dopamine signaling and have been used to treat acute psychosis and long-term conditions like schizophrenia since the 1950s. Whereas haloperidol can reduce psychotic behavior in a few hours, it takes weeks of treatment for patients to see the full effects of the drug. Bowling et al. report that haloperidol induces both short-term and long-term effects on cultured neurons through the Akt-mTOR pathway.