Science Signaling Podcast: 18 February 2014

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Sci. Signal.  18 Feb 2014:
Vol. 7, Issue 313, pp. pc6
DOI: 10.1126/scisignal.2005151

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This Podcast features an interview with Jim Dennis and Mohamed Soliman, authors of a Research Article that appears in the 18 February 2014 issue of Science Signaling, about an adaptor protein that limits glucose uptake metabolism. Adaptor proteins are key components of signal transduction networks because they mediate protein-protein interactions that can promote or block the formation of active signaling complexes. p66Shc is an adaptor protein that participates in signaling by receptor tyrosine kinases and plays a role in glucose metabolism. Mice that lack p66Shc have better glucose tolerance and insulin sensitivity than control mice, so they are resistant to developing diabetes and obesity. Soliman et al. found that at least some of p66Shc's effects on glucose metabolism required the mTOR pathway.

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