Research ArticleMetabolism

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

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Sci. Signal.  18 Feb 2014:
Vol. 7, Issue 313, pp. ra17
DOI: 10.1126/scisignal.2004785

Article Information

vol. 7 no. 313 ra17

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History: 
  • Received October 3, 2013
  • Accepted January 23, 2014

Author Information

  1. Mohamed A. Soliman1,2,3,*,
  2. Anas M. Abdel Rahman1,,
  3. Dudley W. Lamming4,
  4. Kivanç Birsoy4,
  5. Judy Pawling1,
  6. Maria E. Frigolet1,5,
  7. Huogen Lu1,5,
  8. I. George Fantus1,5,
  9. Adrian Pasculescu1,
  10. Yong Zheng1,
  11. David M. Sabatini4,6,7,8,9,
  12. James W. Dennis1,2,*, and
  13. Tony Pawson1,2,
  1. 1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  2. 2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  3. 3Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  4. 4Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  5. 5Banting and Best Diabetes Centre, Toronto General Research Institute, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1L6, Canada.
  6. 6Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  7. 7David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  8. 8Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA.
  9. 9Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
  1. *Corresponding author. E-mail: ma.soliman{at}utoronto.ca (M.A.S.); dennis{at}lunenfeld.ca (J.W.D.)
  • Present address: School of Pharmacy, Yarmouk University, Irbid 21163, Jordan.

  • Deceased.

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