Vol 7, Issue 314
- mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
A kinase complex associated with cellular growth has an unexpected role in muscle atrophy.
- Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism
Arginine methylation stimulates a transcriptional coactivator involved in gluconeogenesis in the liver.
- Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis
The proinflammatory cytokine TNF exacerbates intestinal inflammation by blocking the synthesis of anti-inflammatory steroid hormones.
Apparent redundancy in two yeast osmosensors instead confers specificity in coupling internal and external signals.