Science Signaling Podcast: 4 March 2014

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Sci. Signal.  04 Mar 2014:
Vol. 7, Issue 315, pp. pc7
DOI: 10.1126/scisignal.2005173

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This Podcast features an interview with Geoffrey Abbott, author of a Research Article that appears in the 4 March 2014 issue of Science Signaling, about a potassium channel and a solute transporter that contribute to seizure susceptibility. Mice lacking the potassium channel regulatory subunit KCNE2 have cardiac arrhythmia and are prone to seizures. Abbott et al. report that the cerebrospinal fluid (CSF) from Kcne2−/− mice had decreased abundance of myo-inositol compared to CSF from wild-type mice, and administering myo-inositol rescued seizure susceptibility in Kcne2−/− mice. KNCE2 colocalized with the potassium channel pore-forming subunit KCNQ1 and the myo-inositol transporter SMIT1 in the choroid plexus, the tissue that produces and secretes CSF. The authors identified a mechanism whereby the SMIT1-KCNQ1-KCNE2 complex removes excess myo-inositol from the CSF.

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