Vol 7, Issue 317
- Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway
By ubiquitylating a protein interaction domain in Dishevelled, Huwe1 acts as a negative feedback regulator of Wnt signaling.
- Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling
Nitric oxide exposed to mechanical stress reveals the chemical cues involved in altering Ca2+ signals that lead to arrhythmias.
By binding to Notch target genes, Ikaros shuts off the expression of these genes in T cells and prevents the development of T cell acute lymphoblastic leukemia.