Editors' ChoiceImmunology

Clearance of Chronic Virus

Science Signaling  18 Mar 2014:
Vol. 7, Issue 317, pp. ec73
DOI: 10.1126/scisignal.2005277

The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (see the Perspective by Shlomai and Rice) provide evidence that specific APOBECs mediate the anti-HBV effects of host cytokines, which in turn apparently induce nuclear deaminase activity without damaging host cells. Thus, there may be potential in these findings for developing a therapeutic route to curing chronic HBV infection.

J. Lucifora, Y. Xia, F. Reisinger, K. Zhang, D. Stadler, X. Cheng, M. F. Sprinzl, H. Koppensteiner, Z. Makowska, T. Volz, C. Remouchamps, W.-M. Chou, W. E. Thasler, N. Hüser, D. Durantel, T. J. Liang, C. Münk, M. H. Heim, J. L. Browning, E. Dejardin, M. Dandri, M. Schindler, M. Heikenwalder, U. Protzer, Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343, 1221–1228 (2014). [Abstract] [Full Text]

A. Shlomai, C. M. Rice, Getting rid of a persistent troublemaker to cure hepatitis. Science 343, 1212–1213 (2014). [Abstract] [Full Text]

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