Editors' ChoiceStructural Biology

Crossed Homodimer

Science Signaling  18 Mar 2014:
Vol. 7, Issue 317, pp. ec75
DOI: 10.1126/scisignal.2005280

Our cells respond to infection by releasing interferons, which protect neighboring cells, in part through the cleavage of intracellular RNA by a protein kinase family receptor, RNase L. RNase L is activated by 2′,5′-linked oligoadenylates (the second messenger 2-5 A), sensors of pathogen- and damage-associated RNA. Han et al. report crystal structures of human RNase L in complexes with 2-5 A, nucleotides, and an 18-nucleotide oligomer RNA target.

Y. Han, J. Donovan, S. Rath, G. Whitney, A. Chitrakar, A. Korennykh, Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science 343, 1244–1248 (2014). [Abstract] [Full Text]