Editors' ChoiceNeuroscience

Circadian Rhythms

Sci. Signal.  01 Apr 2014:
Vol. 7, Issue 319, pp. ec87
DOI: 10.1126/scisignal.2005313

Circadian rhythms in the fruit fly Drosophila are driven by neurons in the brain. Yao and Shafer analyzed different sets of neurons that can drive circadian rhythms. Manipulating the period of each set of neurons separately revealed that when the various clock signals were fairly consistent, the fly showed a robust circadian rhythm. But when the various clock signals were seriously out of sync with one another, the fly was oblivious to the day-night cycle.

Z. Yao, O. T. Shafer, The Drosophila circadian clock is a variably coupled network of multiple peptidergic units. Science 343, 1516–1520 (2014). [Abstract] [Full Text]