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This Podcast features an interview with Ann-Kathrin Eisfeld and Albert de la Chapelle, authors of a Research Article that appears in the 15 April 2014 issue of Science Signaling, about a microRNA (miR) that drives acute myeloid leukemia. Acute myeloid leukemia (AML) is a rare form of cancer, but it is the most common form of leukemia that affects adults and has a high mortality rate. The gene encoding miR-3151 is nested within an intron of the BAALC gene. The BAALC/miR-3151 locus has been associated with poor prognosis in a subset of AML patients, but it has been unclear how each gene contributes to cancer. Eisfeld et al. determined that miR-3151 was the primary oncogenic driver at this locus and promoted oncogensis by repressing p53-mediated apoptosis.