PodcastImmunology

Science Signaling Podcast: 22 April 2014

Sci. Signal.  22 Apr 2014:
Vol. 7, Issue 322, pp. pc11
DOI: 10.1126/scisignal.2005355

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Abstract

This Podcast features an interview with José María González-Granado, Francisco Sánchez-Madrid, and Vicente Andrés, authors of a Research Article that appears in the 22 April 2014 issue of Science Signaling, about a component of the nuclear skeleton that promotes T cell activation. Immunological synapses are macromolecular structures that form at sites of contact between T cells and antigen presenting cells. Reorganization of the actin cytoskeleton is important for formation of immunological synapses, optimal signaling through the T cell receptor, and T cell activation. González-Granado et al. found that the abundance of lamin-A, a component of the nuclear lamina, increased during T cell activation. The connection of lamin-A to the cytoskeleton was required for proper cytoskeletal organization at the immunological synapse and for optimal signaling through the T cell receptor.

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