Research ResourceDNA damage

Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

Sci. Signal.  13 May 2014:
Vol. 7, Issue 325, pp. rs3
DOI: 10.1126/scisignal.2005032

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Seq’ing the Depth of the Radiation Response

The DNA damage response (DDR) is critical to the functional integrity of healthy cells exposed to environmental radiation, as well as the survival of cancer cells in response to radiation therapy. The DDR consists of well-characterized protein activation and recruitment pathways that cooperate to repair the damage. Rashi-Elkeles et al. integrated deep sequencing methods to examine the response to ionizing radiation at the genomic level in breast cancer cells. Their findings provide an extensive profile of the transcriptional regulation, epigenetic changes, and involvement of new long noncoding RNAs that are central to this cellular stress response.