Science Signaling Podcast: 20 May 2014

Sci. Signal., 20 May 2014
Vol. 7, Issue 326, p. pc13
DOI: 10.1126/scisignal.2005451

Science Signaling Podcast: 20 May 2014

  1. Renate B. Pilz1 and
  2. Annalisa M. VanHook2
  1. 1Department of Medicine, University of California, San Diego, CA 92093, USA.
  2. 2Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.


This Podcast features an interview with Renate Pilz, senior author of a Research Article that appears in the 20 May 2014 issue of Science Signaling, about how thyroid hormone triggers signaling at the plasma membrane. Thyroid is best known as a ligand for nuclear hormone receptors, which are transcription factors that mediate activation or repression of target genes ligand-dependently. This genomic response to thyroid hormone results in changes in gene expression that, in turn, affect cell biology and metabolism. However, thyroid hormone also elicits rapid, transcription-independent cellular responses by initiating intracellular signaling pathways. Kalyanaraman et al. identified an alternative, membrane-associated form of a nuclear thyroid hormone receptor that mediates nongenomic thyroid hormone signaling in osteoblasts.


R. B. Pilz and A. M. VanHook, Science Signaling Podcast: 20 May 2014. Sci. Signal. 7, pc13 (2014).
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