Research ArticleInterferon Signaling

Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

Sci. Signal.  27 May 2014:
Vol. 7, Issue 327, pp. ra50
DOI: 10.1126/scisignal.2004998

You are currently viewing the editor's summary.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Building a Better Interferon

Type I interferons stimulate an antiviral response during infections, inhibit cells from multiplying, and affect the immune system. The multiplicity of interferon actions complicates their use in patients. Interferons activate two distinct sets of genes: one for the protection against viruses and the other for the antiproliferative and immunomodulatory responses. Levin et al. found that the IFN-α2 variant interferon IFN-1ant prevented other forms of interferon from binding to the interferon receptor. However, at certain concentrations, IFN-1ant activated the genes required for antiviral immunity without activating the genes that suppress cell proliferation. Thus, IFN-1ant might be an effective therapy for treating viral infections.