Editors' ChoiceNeuroscience

High-Definition View of the Synapse

Sci. Signal.  03 Jun 2014:
Vol. 7, Issue 328, pp. ec151
DOI: 10.1126/scisignal.2005540

Individual neurons communicate with one another via their synapses, so to understand the nervous system, we need to understand in detail how the synapses are organized. Wilhelm et al. present a quantitative molecular-scale image of the “average” synapse populated with realistic renditions of each of the protein components that contribute to the inner workings of neurons.

B. G. Wilhelm, S. Mandad, S. Truckenbrodt, K. Kröhnert, C. Schäfer, B. Rammner, S. J. Koo, G. A. Claßen, M. Krauss, V. Haucke, H. Urlaub, S. O. Rizzoli, Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344, 1023–1028 (2014). [Abstract] [Full Text]