Science Signaling Podcast: 3 June 2014

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Science Signaling  03 Jun 2014:
Vol. 7, Issue 328, pp. pc15
DOI: 10.1126/scisignal.2005480

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This Podcast features an interview with Scott Earley, senior author of a Research Article that appears in the 27 May 2014 issue of Science Signaling, about a pressure-sensitive signaling network that controls blood flow in the brain. As blood pressure fluctuates, cerebral arteries respond to maintain a constant flow of blood to the brain. Increasing blood pressure causes stretch-sensitive TRPC6 channels on the surface of the vascular smooth muscle cells to open, thus allowing calcium ions to flow into these cells. This is followed by activation of the nonselective cation channel TRPM4, which allows sodium influx and generates an electrical pulse that causes these cells to contract. Gonzales et al. investigated the signaling network linking the activities of these two channels to vasoconstriction.

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