Research ArticleCancer

The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin β1

Sci. Signal.  17 Jun 2014:
Vol. 7, Issue 330, pp. ra58
DOI: 10.1126/scisignal.2005170

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A Lemur in the Path to Metastasis

Receptor tyrosine kinases regulate many processes in cells, including proliferation and migration. Xu et al. found that Lemur tyrosine kinase 3 (LMTK3), a receptor named for its long intracellular tail, may promote disease progression in breast cancer by inducing the expression of cell adhesion molecules called integrins. LMTK3 was more abundant in breast cancer cells with greater invasive activity in culture and correlated with the abundance of integrin α51 in human breast tumors. Disrupting an intracellular pathway known to induce integrin signaling and cell migration prevented cells that overexpress LMTK3 from migrating through a three-dimensional matrix. The findings identify a new potential target for blocking breast cancer metastasis.